The Committee on Radiation Protection and Public Health (CRPPH) of OECD/Nuclear Energy Agency (NEA) launched the Information System on Occupational Exposure (ISOE) program on 1 January 1992 after two-year pilot program to provide a forum for radiation protection experts from both utilities and national regulatory authorities to discuss, promote and co-ordinate international co-operative undertaking for the radiological protection of workers at nuclear power plants.

Since 1993, The International Atomic Energy Agency (IAEA) has co-sponsored the ISOE Program for those non-NEA member countries.

In 1997, the NEA and IAEA formed a Joint Secretariat.

Japan has been a member since April 1992.
Korea has been a member since October 1996.

ISOE provides a worldwide information exchange system for the optimization of radiological protection of workers in nuclear power plants and the implementation of the ALARA (As Low As Reasonably Achievable) principle.